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This mechanism is different from the previously suggested theory of increasing GSH levels

The antibodies used for the immunoblot assays were: GCLC (Santa Cruz Biotech, #sc-390811), NQO1 (Sigma Prestige Antibodies, HPA007308), ACTIN (Sigma, A1978), NRF2 (Cell Signaling Technology, #12721), NRF1 (Cell Signaling Technology, #8052), YAP/TAZ (Cell Signaling, #8418) 4-HNE (Abcam, #ab46545) and Lamin A/C (Cell Signaling, #4777)

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conducted a study that provided evidence of accumulated damage in mitochondria of T21 fibroblasts, which was found to be associated with an elevated oxidative stress status (Antonaros et al